أبحاث العام 2018


On 2018






Afrose, A. White, E.T., Howes, T., George, G. Rashid, A. Rintoul, L, Islam, N. (2018), Preparation of ibuprofen microparticles by anti-solvent precipitation crystallization (APC) technique: characterization, formulation and in-vitro performance, Journal of Pharmaceutical Sciences, 2018; 107(12):3060-3069.



P.H. Rajasree, WP Chandra P. Sharma, Riyaz Ali M. Osmani, Umme Hani, Atul Srivastava. Eudragit encapsulated cationic poly(lactic-co-glycolic acid) nanoparticles in targeted delivery of capecitabine for augmented colon carcinoma therapy. Journal of drug delivery science and technology. Journal of Drug Delivery Science and Technology. 2018 https://doi.org/10.1016/j.jddst.2018.05.025. (SJR Ranking: Q2)



R. Vaghela , PK. Kulkarnia , Riyaz AMO , VNSK Varma , RR. Bhosale , A Raizadaya , Umme Hani. Design, development and evaluation of mannosylated oral Amphoteri-cin B nanoparticles for anti-leishmanial therapy: Oral kinetics and macrophage uptake studies. Journal of Drug Delivery Science and Technology, 43 (2018) 283–294. (SJR Ranking: Q2)



Riyaz Ali Osmani, Parthasarathi Kulkarni, Shringari Manjunatha, Vishakante Gowda, Umme Hani, Rudra Vaghela, Rohit Bhosale. Cyclodextrin Nanosponges in Drug Delivery and Nanotherapeutics. Environmental Nanotechnology. 279-342 ; 2018.



M.Yasmin Begum, CH.Sirisha , Prathyusha Reddy Gudipati. Formulation and evaluation of Dasatinib loaded solid lipid nanoparticles. International Journal of Pharmacy and Pharmaceuitcal Sciences 2018. 10(12); 14-20



Alsayari, A., Ghazwani, M., Almaghaslah, D., Alhamhoom, Y., Louis, J., Altohami, J., Al-Assiri, G., Alaboghobar, G., Alshahrani, N., Alfaifi, H., and Rajalakshimi, V., Potential Analgesic and Diuretic Activity of Crataegus Oxyacantha Linn. Research J Pharm and Tech, 2018. 11(6): p. 2476-82.



Alsayari, A., Ghazwani, M., Almaghaslah, D., Alhamhoom, Y., Saad, M., Ahmed, R., Saeed, W., Ali, W., and Batool, S., Bombax Ceiba: A Potential Anti-anxiety Drug. Pharmacogn J, 2018. 10(4): p. 712-14.



Al-Sayari, A., Ghazwani, M., Alhamhoom, Y., Almaghaslah, D., Louis, J., and Gurusamy, N., The Antidepressant-like Effect of Almond Oil: An Additive Effect with Lavender Oil. Biomed Res, 2018. 29(18): p. 3402-07.



Rada Ellegå rd, Mohammad Khalid, Cecilia Svanberg, Hanna Holgersson, Ylva Thorén, Mirja Karolina Wittgren, Jorma Hinkula, Sofia Nyströ m, Esaki M. Shankar and Marie Larsson. Frontiers in Immunology. 2018;9:899.



Dalia Almaghaslah, Mohammed Ghazwani, Abdurahman Alsayari, et al. Pharmacy students’ perceptions towards online learningin a Saudi Pharmacy School. Saudi Pharmaceutical Journal 26 (2018) 617-621.




Mohamed Rahamathulla* Comparative Assessment of Different Marketed Brands of Atorvastatin Tablets In Asir Region, Kingdom of Saudi Arabia. MOJ Drug Des Develop Ther. 2018;2 (1):9‒13. DOI:10.15406/mojddt.2018.02.00023



Osman H, Yusufzai SK, Khan MS, Abd Razik BM, Sulaiman O, Mohamad S, Gansau JA, Ezzat MO, Parumasivam T, Hassan MZ. New thiazolyl-coumarin hybrids: Design, synthesis, characterization, X-ray crystal structure, antibacterial and antiviral evaluation, J Mol Str. 2018; 1166: 147-154.



Ahsan MJ, Meena R, Dubey S, Khan V, Manda S, Jadav SS, Sharma P, Geesi MH, Hassan MZ, et.al. Synthesis and biological potentials of some new 1,3,4-oxadiazole analogues, Med Chem Res. 2018; 27: 864-883.



RD Mehta, D Mehta, M Dhanawat, S Yasmin, Y Ansari, V Saini. Unnati Publications, NCR 1, 1-200 (2018/9/13)



S. Tasqeeruddin, Jaber Abdullah Alshehri. Acetic acid Catalyzed an Efficient One-pot Synthesis of Diphenyl-1,2-dihydroquinazoline Derivatives . Indian Journal of Heterocyclic Chemistry,2018, 28, 535-542.



Better agonist for the opioid receptors1. SL Badshah, A Ullah, SS Al-Showiman, YN Mabkhot

Chemistry Central Journal 12 (1), 13



Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents . YN Mabkhot, MM Alharbi, SS Al-Showiman, HA Ghabbour, NA Kheder, ...

Chemistry Central Journal 12 (1), 56



Muscle relaxant activities of pistagremic acid isolated from Pistacia integerrima3. A Rauf, S Bawazeer, G Uddin, BS Siddiqui, H Khan, TB Hadda, .. Mabkhot. Zeitschrift für Naturforschung C 73 (11-12), 413-416



Honokiol: An anticancer lignan4. A Rauf, S Patel, M Imran, A Maalik, MU Arshad, F Saeed, YN Mabkhot, ... Biomedicine & Pharmacotherapy 107, 555-562



Cu (II) and Mn (II) coordination complexes constructed by C linked bispyrazoles: Effect of anions and hydrogen bonding on the self assembly process M El-Massaoudi, S Radi, YN Mabkhot, SS Al–Showiman, HA Ghabbour, ... Inorganica Chimica Acta 482, 411-419



Enaminone-grafted trithiocarbonate with anticancer and antimicrobial activity

YN Mabkhot, JMA Khaled, MA Sultan, FAN Mohammed, NSHA Alharbi, ...

US Patent App. 15/726,263



Synthesis of new pyrazolone-based heterocycles as inhibitors of monoamine oxidase enzymes

TMA Eldebss, XJ Yi, AM Farag, AA Khedr, MM Abdulla, YN Mabkhot

Journal of the Iranian Chemical Society 15 (8), 1785-1800



Bioactive compounds and health benefits of edible Rumex species-A review

AP Mishra, M Sharifi-Rad, MA Shariati, YN Mabkhot, SS Al-Showiman, ...

Cellular and Molecular Biology 64 (8), 27-34



Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus.

A Rauf, U Shaheen, M Raza, G Uddin, TB Hadda, YN Mabkhot, N Jehan, ...

Pakistan journal of pharmaceutical sciences 31 (3)



Cholinesterase Inhibitory Activity of Some Semi-rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site

TB Hadda, O Talhi, ASM Silva, FS Senol, IE Orhan, A Rauf, YN Mabkhot, ...

Mini reviews in medicinal chemistry 18 (8), 711-716



Synthesis, X-ray Crystal Structures, Computational Studies and Catechol Oxidase Activity of New Acylhydrazone Derivatives




Isolation and Characterization of Two New Antimicrobial Acids from Quercus incana (Bluejack Oak)

R Sarwar, U Farooq, S Naz, N Riaz, S Majid Bukhari, A Rauf, YN Mabkhot, ...

BioMed research international 2018



Novel 1D coordination polymers built from acyclic cryptate containing bis (1 H-1, 2, 4-triazole) ligands and featuring coordinated counteranions

M El-Massaoudi, S Radi, A Salhi, YN Mabkhot, SS Al-Showiman, ...

New Journal of Chemistry 42 (14), 11324-11333



Bioactive chromone constituents from Vitex negundo alleviate pain and inflammation

A Khan, S Naz, U Farooq, M Shahid, I Ullah, I Ali, A Rauf, YN Mabkhot

Journal of pain research 11, 95



Synthesis and pharmacological activities of pyrazole derivatives: a review

K Karrouchi, S Radi, Y Ramli, J Taoufik, Y Mabkhot, F Al-aizari

Molecules 23 (1), 134



Increasing the strength and production of artemisinin and its derivatives

S Badshah, A Ullah, N Ahmad, Z Almarhoon, Y Mabkhot

Molecules 23 (1), 100



Atiya A, Sinha BN, Lal UR . 2018 The new ether derivative of phenylpropanoid and bioactivity was investigated from the leaves of Piper betle L.Nat Prod Res. 31: 2604-2611.





Rizvi A, Wahab S, Mahdi AA, Misra A, et al. Protective effects of Butea frondosa leaves against stress induced immune impairment in sprague dawley rats.  Pak. J. Pharm. Sci 2018;31 2457-2462.




Ahmad P, Adak M, Wahab S, et al. Ameliorative Potential of Euphorbia hirta (Linn.) Extract against Lipopolysaccharide Induced-neuroinflammation and Oxidative Damage in Rats. Biochem Pharmacol (Los Angel). 2018; 7: 253-257.



Youness RA, Assal RA, Ezzat SM, Gad MZ, Abdel Motaal AA (2018). A methoxylated quercetin glycoside harnesses HCC tumor progression in a P53/miR-15/miR-16 dependent manner. Natural Product Research, https://doi.org/10.1080/14786419.2018.1509326



Youness RA, Assal RA, Abdel Motaal A, Gad MZ (2018). A novel role of sONE/NOS3/NO signaling cascade in mediating hydrogen sulphide bilateral effects on triple negative breast cancer progression. Nitric Oxide, 80, 12-23.



Sara Gabr, Stefanie Nikles, Eva Maria Pferschy Wenzig, Karin Ardjomand-Woelkart, Rania M.Hathout, Sherweit El-Ahmady, Amira Abdel Motaal, Abdelnasser Singab, Rudolf Bauer (2018). Characterization and optimization of phenolics extracts from Acacia species in relevance to their anti-inflammatory activity. Biochemical Systematics and Ecology, 78, 21-30.



Mohamed Ali, Amira Abdel Motaal , Mohammed A. Ahmed , Abdulrhman Alsayari and Omaima N. El-Gazayerly (2018). An in vivo study of Hypericum perforatum in a niosomal topical drug delivery system. Drug Delivery, 25 (1), 417-425.



Khalil NA, Abdel Motaal A, Meselhy K, Abdel Khalek SM (2018). Renin and Angiotensin converting enzyme inhibition of standardized bioactive fractions of Hyphaene Thebaica L. Mart growing in Egypt. Pharmacognosy Journal, 10 (4), 622-627.



Ola M. Abdallaha, Amira Abdel Motaal, Sara A.A. Elbahrawya (2018). Development of a Validated Reversed Phase HPLC-UV Method for a Simultaneous Determination of Hederacoside C and Thymol in Ivy-Thyme Cough Syrup. Chemistry Research Journal, 3(2), 33-41.



Alsayari A, Almghaslah D, Khaled A, Annadurai S, Alkhairy MA, Alqahtani HA, Alsayed BA, Alasiri RM, Assiri AM. Community Pharmacists’ Knowledge, Attitudes, and Practice of Herbal Medicines in Asir Region, Kingdom of Saudi Arabia Evidence-Based Complementary and Alternative Medicine, Volume 2018, Article ID 1568139, 7 pages



Alsayari A, Kopel L, Ahmed SM, Soliman HSM, Annadurai S, Halaweish FT.  Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation, BMC Complementary and Alternative Medicine (2018) volume 18, Article number: 274 



  1. Pitchai Balakumar, Ramanathan Sambathkumar, Nanjaian Mahadevan, Abdullatif Bin Muhsinah, Abdulrhman Alsayari, Nallasamy Venkateswaramurthy, Sokkalingam A. Dhanaraj, Molecular targets of fenofibrate in the cardiovascular-renal axis: A unifying perspective of its pleiotropic benefits. Pharmacological Research. 2019: 144 : 132–141



  1. Pitchai Balakumar, Nanjaian Mahadevan and Ramanathan Sambathkumar, A Contemporary Overview of PPARα/γ Dual Agonists for the Management of Diabetic Dyslipidemia. Current Molecular Pharmacology. 2019, 12(3), 195-201.



  1. Pitchai Balakumar, Ramanathan Sambathkumar, Nanjaian Mahadevan, Abdullatif Bin Muhsinah, Abdulrhman Alsayari, Nallasamy Venkateswaramurthy, Gowraganahalli Jagadeesh, A potential role of the renin-angiotensin-aldosterone system in epithelial-to mesenchymal transition-induced renal abnormalities: Mechanisms and therapeutic implications, Pharmacological Research. 2019: 146: 1-7



 Abdulrahman Alsayari, Rajalakshimi.V* et.al., Potential analgesic and diuretic activity of Crataegus oxyacantha Linn. Research J. Pharm. and Tech. 2018; 11(6): 2476-2482.




 Abdulrahman Alsayari, Sadia Batool* et al. Bombax ceiba: A Potential Anti-Anxiety Drug. Pharmacognosy Journal, 2018,10,4,712-714.




 Yasmin Begum, Rajalakshimi et.al., Comparison of topical 1% diclofenac sodium gel and its performance with marketed gel (Rofenac). International Journal of Research in Pharmaceutical Sciences. 2018; 10(1); 158-164.




 Sadia Batool Shahid*. Subclinical Hypothyroidism and its Associated Disorders. Thyroid Disorders Ther. 2018, 7:2




 Asiri YI, Fung T, Schwarz SKW, Asseri KA, Welch ID, Schuppli CA, Barr AM, Wall RA, Puil E, MacLeod BA. "An intraplantar hypertonic saline assay in mice for rapid screening of analgesics." Anesthesia & Analgesia 127.2 (2018): 548-555.




 Asiri YI, Fung T, et al. "An intraplantar hypertonic saline assay in mice for rapid screening of analgesics." Anesthesia & Analgesia 127.2 (2018): 548-555.




 Thilagam E, CT. Kumarappan and Subhash C Mandal. Antidiabetic activity of Senna surattensis in alloxan-induced diabetic rats. Asian Journal of Pharmaceutical and Clinical Research, 2018




KenichiWatanabea, Vengadeshprabhu Karuppagounder, RemyaSreedhar,

Geetha Kandasamy, Meilei Harima, Ravichandiran Velayutham,

Somasundaram Arumugam. Basidiomycetes-X, an edible mushroom, alleviates

the development of atopic dermatitis in NC/Nga mouse model. Experimental

and molecular pathology 2018; 105:322-327.



Sadia Shah, Md. Sayeed Akhtar, Md. Quamrul. Hassan, Mohd. Akhtar , Yam Nath Paudel,

Abul Kalam Najmi. EGFR tyrosine kinase inhibition decreases collagen deposition and

ameliorates SERCA2a/NCX1 in C57/BL6 mice against diabetic cardiomyopathy. Life Science.

2018; 210: 29-39. IF:3.23



Nimisha Tandon, Madhuri Kulkarni, Sowmya GS, Fauzia Tabassum, Md Sayeed Akhtar.

prevalence of inducible clindamycin resistance in clinical isolates of methicillin-resistant

staphylococcus aureus mediated through gene ermc expression. AJPCR Vol 11, Issue 9, 2018.



Ramsha Iqbal, Md. Sayeed Akhtar, Zeeba S. Jairajpuri, Md. Quamrul Hassan, Mohd. Akhtar,

Abul Kalam Najmi. Pitavastatin ameliorates myocardial damage by preventing inflammation

and collagen deposition via reduced free radical generation in isoproterenol induced

cardiomyopathy. Clinical and Experimental Pharmacology 2018; 7: 1-10 IF 1.3



Mohd Imran, Md Quamrul Hassan, Md, Sayeed Akhtar, Md Obaid rahman, Mohd Akhtar,

Abul Kalam Najmi. Sacubitril and valsartan protect from experimental myocardial infarction by

ameliorating oxidative damage in Wistar rats. Clinical and Experimental Pharmacology

2018; 29: 1-8. IF 1.3



Md jawaid Akhtar, Ahsan Ahmad Khan, Zulphikar Ali, Rikeshwer Prasad Dewangan, Md Rafi,

Md Quamrul Hassan, Md Sayeed Akhtar, Anees Ahmad Siddiqui, Sangh Partap, Santosh

Pasha. Synthesis of stable benzimidazole derivatives bearing pyrazole as anticancer and

EGFR receptor inhibitors. Bioorganic Chemistry 2018; 78: 158-169. IF: 3.93



Alakhali KM, Vigneshwaran E, Shaik Mohammad Asif Ansari. Effect of food and antacid

on simvastatin bioavailability on healthy adult volunteers. J Health Res Rev 2018;5:26-32.



               Singh S, McDonough CW, Gong Y, Alghamdi WA, Arwood MJ, Bargal SA, Dumeny L, Li WY,

Mehanna M, Stockard B, Yang G, de Oliveira FA, Fredette NC, Shahin MH, Bailey KR,

Beitelshees AL, Boerwinkle E, Chapman AB, Gums JG, Turner ST, Cooper-DeHoff RM,

Johnson JA. Genome wide association study identifies the HMGCS2 locus to be associated

with chlorthalidone induced glucose increase in hypertensive patients. J Am Heart Assoc.




Alghamdi WA, Al-Shaer MH, Peloquin CA. Protein Binding of First-Line Antituberculosis

Drugs. Antimicrob Agents Chemother. 2018;62(7).



Lange C, Alghamdi WA, Al-Shaer MH, Brighenti S, Diacon AH, DiNardo AR, Grobbel HP,

Gröschel MI, von Groote-Bidlingmaier F, Hauptmann M, Heyckendorf J, Köhler N, Kohl TA,

Merker M, Niemann S, Peloquin CA, Reimann M, Schaible UE, Schaub D, Schleusener V, Thye

T, Schön T. Perspectives for personalized therapy for patients with multidrug-resistant

tuberculosis. J Intern Med. 2018.



Huston R.K., Christensen J.M.; Alshahrani SM., Mohamed S.M., Heisel C.F. Calcium Chloride and Calcium Gluconate in Neonatal Parenteral Nutrition Solutions without Cysteine: Compatibility Studies Using Laser Light Obscuration Methodology. Nutrients 2018, 10, 208.



Ali M, Abdel Motaal A, Ahmed MA, Alsayari A, El-Gazayerly ON. An in vivo study of Hypericum perforatum in a niosomal topical drug delivery system. Drug Deliv. 2018 Jan




Almaghaslah D, Ghazwani M, Alsayari A, Khaled A. Pharmacy students' perceptions towards online learning in a Saudi Pharmacy School. Saudi Pharm J. 2018 Mar5



Alsayari A, Ghazwani M, Almaghaslah D, Alhamhoom Y, Saad M, Ahmed R, Saeed W, Ali W, Batool S. Bombax ceiba: A Potential Anti-Anxiety Drug. Pharmacognosy Journal. 2018 May



Alsayari A, Ghazwani M, Almaghaslah D, Alhamhoom Y, Louis J, Altohami J, AlAssiri GM, Alaboghobar GS, Alshahrani N, Alfaifi HH, Rajalakshimi V. Potential analgesic and diuretic activity of Crataegus oxyacantha Linn. Research Journal of Pharmacy and Technology. 2018 Jul



Alsayari A, Halaweish FT, Gurusamy N. The role of cucurbitacins in combating cancers: A mechanistic review. Pharmacogn Rev. 2018 Jul-Dec.



Alsayari A, Almghaslah D, Khaled A, Annadurai S, Alkhairy MA, Alqahtani HA, Alsayed BA, Alasiri RM, Assiri AM. Community Pharmacists' Knowledge, Attitudes, and Practice of Herbal Medicines in Asir Region, Kingdom of Saudi Arabia. Evid Based Complement Alternat Med. 2018 Aug 30



Gurusamy N, Alsayari A, Rajasingh S, Rajasingh J. Adult Stem Cells for Regenerative Therapy. Progress in Molecular Biology and Translational Science.2018 Sep 6



Almaghaslah D, Alsayari A, Asiri R, Albugami N. Pharmacy workforce in Saudi Arabia: Challenges and opportunities: A cross-sectional study. Int J Health Plann Manage. 2018 Sep 28



Alsayari A, Kopel L, Ahmed MS, Soliman HSM, Annadurai S, Halaweish FT. Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation. BMC Complement Altern Med. 2018 Oct 9.



El-Askary H, Handoussa H, Badria F, El-Khatib A H, Alsayari A, Linscheid MW, AbdelMotaal A. Characterization of hepatoprotective metabolites from Artemisia annua and Cleome droserifolia using HPLC/PDA/ESI/MS–MS. Revista Brasileira de Farmacognosia. 2018 Oct 16



Alsayari A, Ghazwani M, Alhamhoom Y, Almaghaslah D, Louis J, Gurusamy N. The antidepressant-like effect of almond oil: An additive effect with lavender oil. Biomedical Research. 2018 Oct